abstract：:Clustering individuals to subpopulations based on genetic data has become commonplace in many genetic studies. Inference about population structure is most often done by applying model-based approaches, aided by visualization using distance-based approaches such as multidimensional scaling. While existing distance-bas...

journal_title：Genetics

authors： Greenbaum G,Templeton AR,Bar-David S

更新日期：2016-04-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have been widely used for identifying common variants associated with complex diseases. Despite remarkable success in uncovering many risk variants and providing novel insights into disease biology, genetic variants identified to date fail to explain the vast majority of the heri...

journal_title：Genetics

authors： Huang J,Wang K,Wei P,Liu X,Liu X,Tan K,Boerwinkle E,Potash JB,Han S

更新日期：2016-03-01 00:00:00

abstract：:Understanding the transmission dynamics of infectious diseases is important for both biological research and public health applications. It has been widely demonstrated that statistical modeling provides a firm basis for inferring relevant epidemiological quantities from incidence and molecular data. However, the comp...

journal_title：Genetics

authors： Lintusaari J,Gutmann MU,Kaski S,Corander J

更新日期：2016-03-01 00:00:00

abstract：:The noncanonical Frizzled/planar cell polarity (PCP) pathway regulates establishment of polarity within the plane of an epithelium to generate diversity of cell fates, asymmetric, but highly aligned structures, or to orchestrate the directional migration of cells during convergent extension during vertebrate gastrulat...

journal_title：Genetics

authors： Dollar G,Gombos R,Barnett AA,Sanchez Hernandez D,Maung SM,Mihály J,Jenny A

更新日期：2016-03-01 00:00:00

abstract：:RNA editing refers to post-transcriptional processes that alter the base sequence of RNA. Recently, hundreds of new RNA editing targets have been reported. However, the mechanisms that determine the specificity and degree of editing are not well understood. We examined quantitative variation of site-specific editing i...

journal_title：Genetics

authors： Gu T,Gatti DM,Srivastava A,Snyder EM,Raghupathy N,Simecek P,Svenson KL,Dotu I,Chuang JH,Keller MP,Attie AD,Braun RE,Churchill GA

更新日期：2016-02-01 00:00:00

abstract：:Nucleosome-depleted regions (NDRs) are present immediately adjacent to the transcription start site in most eukaryotic promoters. Here we show that NDRs in the upstream promoter region can profoundly affect gene regulation. Chromatin at the yeast HO promoter is highly repressive and numerous coactivators are required ...

journal_title：Genetics

authors： Yarrington RM,Goodrum JM,Stillman DJ

更新日期：2016-02-01 00:00:00

abstract：:We consider resequencing studies of associated loci and the problem of prioritizing sequence variants for functional follow-up. Working within the multivariate linear regression framework helps us to account for the joint effects of multiple genes; and adopting a Bayesian approach leads to posterior probabilities that...

journal_title：Genetics

authors： Stell L,Sabatti C

更新日期：2016-02-01 00:00:00

abstract：:Low-coverage next-generation sequencing methodologies are routinely employed to genotype large populations. Missing data in these populations manifest both as missing markers and markers with incomplete allele recovery. False homozygous calls at heterozygous sites resulting from incomplete allele recovery confound man...

journal_title：Genetics

authors： Fragoso CA,Heffelfinger C,Zhao H,Dellaporta SL

更新日期：2016-02-01 00:00:00

abstract：:Additive genetic variance in natural populations is commonly estimated using mixed models, in which the covariance of the genetic effects is modeled by a genetic similarity matrix derived from a dense set of markers. An important but usually implicit assumption is that the presence of any nonadditive genetic effect in...

journal_title：Genetics

authors： Kruijer W

更新日期：2016-01-01 00:00:00

abstract：:Movement of transposons causes insertions, deletions, and chromosomal rearrangements potentially leading to premature lethality in Drosophila melanogaster. To repress these elements and combat genomic instability, eukaryotes have evolved several small RNA-mediated defense mechanisms. Specifically, in Drosophila somati...

journal_title：Genetics

authors： Russo J,Harrington AW,Steiniger M

更新日期：2016-01-01 00:00:00

abstract：:Germ cell specification as sperm or oocyte is an ancient cell fate decision, but its molecular regulation is poorly understood. In Caenorhabditis elegans, the FOG-1 and FOG-3 proteins behave genetically as terminal regulators of sperm fate specification. Both are homologous to well-established RNA regulators, suggesti...

journal_title：Genetics

authors： Noble DC,Aoki ST,Ortiz MA,Kim KW,Verheyden JM,Kimble J

更新日期：2016-01-01 00:00:00

abstract：:Molecular heterogeneity in human breast cancer has challenged diagnosis, prognosis, and clinical treatment. It is well known that molecular subtypes of breast tumors are associated with significant differences in prognosis and survival. Assuming that the differences are attributed to subtype-specific pathways, we then...

journal_title：Genetics

authors： Li R,Campos J,Iida J

更新日期：2015-12-01 00:00:00

abstract：:It is well known that most new mutations that affect fitness exert deleterious effects and that natural populations are often composed of subpopulations (demes) connected by gene flow. To gain a better understanding of the joint effects of purifying selection and population structure, we focus on a scenario where an a...

journal_title：Genetics

authors： Zeng K,Corcoran P

更新日期：2015-12-01 00:00:00

abstract：:Transposable element activity is repressed in the germline in animals by PIWI-interacting RNAs (piRNAs), a class of small RNAs produced by genomic loci mostly composed of TE sequences. The mechanism of induction of piRNA production by these loci is still enigmatic. We have shown that, in Drosophila melanogaster, a clu...

journal_title：Genetics

authors： Hermant C,Boivin A,Teysset L,Delmarre V,Asif-Laidin A,van den Beek M,Antoniewski C,Ronsseray S

更新日期：2015-12-01 00:00:00

abstract：:In finite populations, an allele disappears or reaches fixation due to two main forces, selection and drift. Selection is generally thought to accelerate the process: a selected mutation will reach fixation faster than a neutral one, and a disadvantageous one will quickly disappear from the population. We show that ev...

journal_title：Genetics

authors： Mafessoni F,Lachmann M

更新日期：2015-12-01 00:00:00

abstract：:We present a Bayesian method for characterizing the mating system of populations reproducing through a mixture of self-fertilization and random outcrossing. Our method uses patterns of genetic variation across the genome as a basis for inference about reproduction under pure hermaphroditism, gynodioecy, and a model de...

journal_title：Genetics

authors： Redelings BD,Kumagai S,Tatarenkov A,Wang L,Sakai AK,Weller SG,Culley TM,Avise JC,Uyenoyama MK

更新日期：2015-11-01 00:00:00

abstract：:Transposable elements (TEs) constitute a substantial fraction of the eukaryotic genome and, as a result, have a complex relationship with their host that is both adversarial and dependent. To minimize damage to cellular genes, TEs possess mechanisms that target integration to sequences of low importance. However, the ...

journal_title：Genetics

authors： Hickey A,Esnault C,Majumdar A,Chatterjee AG,Iben JR,McQueen PG,Yang AX,Mizuguchi T,Grewal SI,Levin HL

更新日期：2015-11-01 00:00:00

abstract：:The breeding systems of many organisms are cryptic and difficult to investigate with observational data, yet they have profound effects on a species' ecology, evolution, and genome organization. Genomic approaches offer a novel, indirect way to investigate breeding systems, specifically by studying the transmission of...

journal_title：Genetics

authors： Svendsen N,Reisser CM,Dukić M,Thuillier V,Ségard A,Liautard-Haag C,Fasel D,Hürlimann E,Lenormand T,Galimov Y,Haag CR

更新日期：2015-11-01 00:00:00

abstract：:Although maize is naturally an outcrossing organism, modern breeding utilizes highly inbred lines in controlled crosses to produce hybrids. The U.S. Department of Agriculture's reciprocal recurrent selection experiment between the Iowa Stiff Stalk Synthetic (BSSS) and the Iowa Corn Borer Synthetic No. 1 (BSCB1) popula...

journal_title：Genetics

authors： Gerke JP,Edwards JW,Guill KE,Ross-Ibarra J,McMullen MD

更新日期：2015-11-01 00:00:00

abstract：:Fruit flies of the genus Drosophila have been an attractive and effective genetic model organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them a century ago. Work with Drosophila has enabled dramatic advances in cell and developmental biology, neurobiology and behavior, molecular biology, ...

journal_title：Genetics

authors： Hales KG,Korey CA,Larracuente AM,Roberts DM

更新日期：2015-11-01 00:00:00

abstract：:There is increasing recognition that genetic diversity can affect the spread of diseases, potentially affecting plant and livestock disease control as well as the emergence of human disease outbreaks. Nevertheless, even though computational tools can guide the control of infectious diseases, few epidemiological models...

journal_title：Genetics

authors： Anacleto O,Garcia-Cortés LA,Lipschutz-Powell D,Woolliams JA,Doeschl-Wilson AB

更新日期：2015-11-01 00:00:00

abstract：:Gene targeting techniques have led to the phenotypic characterization of numerous genes; however, many genes show minimal to no phenotypic consequences when disrupted, despite many having highly conserved sequences. The standard explanation for these findings is functional redundancy. A competing hypothesis is that th...

journal_title：Genetics

authors： Ruff JS,Saffarini RB,Ramoz LL,Morrison LC,Baker S,Laverty SM,Tvrdik P,Potts WK

更新日期：2015-10-01 00:00:00

abstract：:Use of the CRISPR/Cas9 RNA-guided endonuclease complex has recently enabled the generation of double-strand breaks virtually anywhere in the C. elegans genome. Here, we present an improved strategy that makes all steps in the genome editing process more efficient. We have created a toolkit of template-mediated repair ...

journal_title：Genetics

authors： Norris AD,Kim HM,Colaiácovo MP,Calarco JA

更新日期：2015-10-01 00:00:00

abstract：:Tetrahymena is a useful eukaryotic model for biochemistry and molecular cell biology studies. We previously demonstrated that targeted ectopic DNA elimination, also called co-Deletion (coDel), can be induced by the introduction of an internal eliminated sequence (IES)-target DNA chimeric construct. In this study, we d...

journal_title：Genetics

authors： Hayashi A,Mochizuki K

更新日期：2015-09-01 00:00:00

abstract：:Individuals within a species vary in their responses to a wide range of stimuli, partly as a result of differences in their genetic makeup. Relatively little is known about the genetic and neuronal mechanisms contributing to diversity of behavior in natural populations. By studying intraspecies variation in innate avo...

journal_title：Genetics

authors： Ghosh R,Bloom JS,Mohammadi A,Schumer ME,Andolfatto P,Ryu W,Kruglyak L

更新日期：2015-08-01 00:00:00

abstract：:Biological robustness, the ability of an organism to maintain a steady-state output as genetic or environmental inputs change, is critical for proper development. MicroRNAs have been implicated in biological robustness mechanisms through their post-transcriptional regulation of genes and gene networks. Previous resear...

journal_title：Genetics

authors： Burke SL,Hammell M,Ambros V

更新日期：2015-08-01 00:00:00

abstract：:While the approximate chromosomal position of centromeres has been identified in many species, little is known about the dynamics and diversity of centromere positions within species. Multiple lines of evidence indicate that DNA sequence has little or no impact in specifying centromeres in maize and in most multicellu...

journal_title：Genetics

authors： Gent JI,Wang K,Jiang J,Dawe RK

更新日期：2015-08-01 00:00:00

abstract：:The Drosophila melanogaster sex-peptide (melSP) is a seminal fluid component that induces postmating responses (PMR) of females via the sex-peptide receptor (SPR) . Although SP orthologs are found in many Drosophila species, their functions remain poorly characterized. It is unknown whether SP functions are conserved ...

journal_title：Genetics

authors： Tsuda M,Peyre JB,Asano T,Aigaki T

更新日期：2015-08-01 00:00:00

abstract：:The Genetics Society of America's George W. Beadle Award honors individuals who have made outstanding contributions to the community of genetics researchers and who exemplify the qualities of its namesake as a respected academic, administrator, and public servant. The 2015 recipient is John Postlethwait. He has made g...

journal_title：Genetics

authors： Postlethwait JH

更新日期：2015-07-01 00:00:00

abstract：:We analyze two models of the maintenance of quantitative genetic variance in a mixed-mating system of self-fertilization and outcrossing. In both models purely additive genetic variance is maintained by mutation and recombination under stabilizing selection on the phenotype of one or more quantitative characters. The ...

journal_title：Genetics

authors： Lande R,Porcher E

更新日期：2015-07-01 00:00:00

abstract：:Rapid and high wing-beat frequencies achieved during insect flight are powered by the indirect flight muscles, the largest group of muscles present in the thorax. Any anomaly during the assembly and/or structural impairment of the indirect flight muscles gives rise to a flightless phenotype. Multiple mutagenesis scree...

journal_title：Genetics

authors： Firdaus H,Mohan J,Naz S,Arathi P,Ramesh SR,Nongthomba U

更新日期：2015-05-01 00:00:00

abstract：:In contrast to our growing understanding of patterns of additive genetic variance in single- and multi-trait combinations, the relative contribution of nonadditive genetic variance, particularly dominance variance, to multivariate phenotypes is largely unknown. While mechanisms for the evolution of dominance genetic v...

journal_title：Genetics

authors： Sztepanacz JL,Blows MW

更新日期：2015-05-01 00:00:00

abstract：:The identity of a given cell type is determined by the expression of a set of genes sharing common cis-regulatory motifs and being regulated by shared transcription factors. Here, we identify cis and trans regulatory elements that drive gene expression in the bilateral sensory neuron ASJ, located in the head of the ne...

journal_title：Genetics

authors： González-Barrios M,Fierro-González JC,Krpelanova E,Mora-Lorca JA,Pedrajas JR,Peñate X,Chavez S,Swoboda P,Jansen G,Miranda-Vizuete A

更新日期：2015-05-01 00:00:00

abstract：:The parasitoid wasp Nasonia represents a genus of four species that is emerging as a powerful genetic model system that has made and will continue to make important contributions to our understanding of evolutionary biology, development, ecology, and behavior. Particularly powerful are the haplodiploid genetics of the...

journal_title：Genetics

authors： Lynch JA

更新日期：2015-04-01 00:00:00

abstract：:Genetic screens in Drosophila melanogaster and other organisms have been pursued to filter the genome for genetic functions important for memory formation. Such screens have employed primarily chemical or transposon-mediated mutagenesis and have identified numerous mutants including classical memory mutants, dunce and...

journal_title：Genetics

authors： Walkinshaw E,Gai Y,Farkas C,Richter D,Nicholas E,Keleman K,Davis RL

更新日期：2015-04-01 00:00:00

abstract：:Understanding adaptive genetic responses to climate change is a main challenge for preserving biological diversity. Successful predictive models for climate-driven range shifts of species depend on the integration of information on adaptation, including that derived from genomic studies. Long-lived forest trees can ex...

journal_title：Genetics

authors： Jaramillo-Correa JP,Rodríguez-Quilón I,Grivet D,Lepoittevin C,Sebastiani F,Heuertz M,Garnier-Géré PH,Alía R,Plomion C,Vendramin GG,González-Martínez SC

更新日期：2015-03-01 00:00:00

abstract：:The presence of large genomic regions with suppressed recombination (SR) is a key shared property of some sex- and mating-type determining (mat) chromosomes identified to date in animals, plants, and fungi. Why such regions form and how they evolve remain central questions in evolutionary genetics. The smut fungus Mic...

journal_title：Genetics

authors： Whittle CA,Votintseva A,Ridout K,Filatov DA

更新日期：2015-03-01 00:00:00

abstract：:Accounting for gene-environment (G×E) interactions in complex trait association studies can facilitate our understanding of genetic heterogeneity under different environmental exposures, improve the ability to discover susceptible genes that exhibit little marginal effect, provide insight into the biological mechanism...

journal_title：Genetics

authors： Zhao G,Marceau R,Zhang D,Tzeng JY

更新日期：2015-03-01 00:00:00

abstract：:The essential neurotransmitter acetylcholine functions throughout the animal kingdom. In Caenorhabditis elegans, the acetylcholine biosynthetic enzyme [choline acetyltransferase (ChAT)] and vesicular transporter [vesicular acetylcholine transporter (VAChT)] are encoded by the cha-1 and unc-17 genes, respectively. Thes...

journal_title：Genetics

authors： Mathews EA,Mullen GP,Manjarrez JR,Rand JB

更新日期：2015-03-01 00:00:00

abstract：:Two alternative hypotheses attribute different benefits to codon-anticodon adaptation. The first assumes that protein production is rate limited by both initiation and elongation and that codon-anticodon adaptation would result in higher elongation efficiency and more efficient and accurate protein production, especia...

journal_title：Genetics

authors： Xia X

更新日期：2015-02-01 00:00:00